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The most common cause of cardiac arrest is coronary artery disease. Less common causes include major blood loss, lack of oxygen, very low potassium, heart failure, and intense physical exercise. –Ischemia - blood flow –Anoxia - lack of O 2 ( due to blood clot) –Cellular responses •Decrease in ATP, causing failure of Na-K pump and sodium-calcium exchange •Cellular swelling •Vacuolation (formation of vacuoles) –If O 2 restored Reperfusion injury free radicals Cellular Injury Cellular Injury Mechanisms

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Complications may adversely affect the prognosis, or outcome, of a disease. Complications generally involve a worsening in severity of disease or the development of new signs, symptoms, or pathological changes which may become widespread…

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